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Source: Arrone, et al New England J of Medicine May 11, 2025 Researchers randomized about 1,500 people with obesity and without diabetes to be treated with either tirzepatide or semaglutide, both at the highest tolerable recommended doses, and followed them for 72 weeks

Store reconstituted solution at 2 to 8C for up to 14 days

However, liver function should be monitored during treatment, particularly during dose escalation when the metabolic demands on the liver increase

How should GLP-1s be paired with metabolic carefueling, sleep, movement, and real clinical oversight

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